Representative
Representative Profile
Kazuhiko Shibata
Kazuhiko Shibata
Representative Director & President, Artisan Lab Co., Ltd.
Career & Affiliations
- ▸Yokohama City University School of Medicine, Dept. of Cardiology, Nephrology & Hypertension Visiting Associate Professor (Apr 2025–) → Visiting Professor (Apr 2026–present)
- ▸Artisan Lab Co., Ltd. (Meguro, Tokyo) — Representative Director & President
Society Memberships
- ▸Japanese Society for Dialysis Therapy (June 1990–present)
R&D & Societal Implementation
To address challenges in clinical practice, he conducts R&D and patent acquisition for innovative medical devices and pharmaceuticals using new materials.
Patents, Press Releases & Media Coverage
Next-Generation Hemostatic Agent & Wound Dressing Based on Cationic Cellulose
Developed an innovative hemostatic pad that overcomes allergy and other risks of conventional chitosan-based hemostatics, dramatically reducing post-dialysis bleeding time (average under 3 minutes). Commercialized by Nipro Corporation.
[Patent Publication No.] WO2019026177A1
[Patent Publication No.] JP2017140231A (co-filed by Artisan Lab Co., Ltd. and Nipro Corporation)
[Media]Nikkei (Japanese)
Development of a More Powerful Hemostatic Substance: Cationic Guar Gum (International Patent)
Development of various new hemostatic agents based on cationic guar gum, which surpasses the performance of cationic cellulose.
[Patent Publication No.] WO2022191330A1 et al. (co-filed by Artisan Lab Co., Ltd. and Nipro Corporation)
[Media]Google Patents
Discovery of an Anti-Diabetic Substance from Euglena (Microalgae)
Discovered a linear cationic polysaccharide derived from paramylon (a component accumulated by Euglena) that promotes secretion of the "slimming hormone" GLP-1. A groundbreaking invention that improves glucose and lipid metabolism, developed in joint research with AIST.
[Patent Publication No.] JP2019099508A / WO2019107471A1 (co-filed by Artisan Lab Co., Ltd., AIST, and Kobelco Eco-Solutions)
[Media]AIST Official Release
Patent on Safe Puncture Needle Structure for Dialysis
Development of a novel puncture needle designed to enable safer clean buttonhole cannulation by relieving puncture pain and significantly reducing the risk of local infection caused by scab displacement.
[Patent Publication No.] WO2018221536A1 (Applicant: Artisan Lab Co., Ltd.)
Patent on Blood Purification Device & Access Flow Rate (US Patent, etc.)
System patent related to dialysis circuits and blood purification devices.
[Patent Publication No.] Registered July 2022 — "BLOOD PURIFYING DEVICE AND ACCESS FLOW RATE" (co-filed by Artisan Lab Co., Ltd. and Nipro Corporation)
Key Publications & Achievements
He has authored numerous papers in international peer-reviewed journals, focusing on improvements to puncture techniques in dialysis (clean buttonhole method), medical safety (air bubble elimination device), and body fluid measurement. He has continuously presented research findings at ERA (European Renal Association – European Dialysis and Transplant Association), one of the world's largest nephrology congresses.
Moist Wound Healing and Eutectic Mixture of Local Anesthetics Cream for Clean Buttonhole Cannulation
Kidney360, October 2025
Summary: Use of moist wound healing and local anesthetic cream for clean buttonhole cannulation
Novel Capped-Needle Device: A Novel Safety Feature to Eliminate Air Bubbles in Hemodialysis
Blood Purification, 2023
Summary: Development of a novel capped-needle device to eliminate air bubbles during dialysis
Comparison of Body Fluid Volumes Determined by Kinetic Modeling and by Bioimpedance Spectroscopy
Blood Purification, 2022
Summary: Comparison of body fluid volumes using kinetic modeling and bioimpedance spectroscopy
Prevalence of mild cognitive impairment and its association with handgrip strength in patients on hemodialysis.
Scientific Reports, March 9, 2022
Summary: Prevalence of mild cognitive impairment and its association with handgrip strength in hemodialysis patients
DOI: 10.1038/s41598-022-07550-4MO665 THE BRAND-NEW NEEDLE CAP ELIMINATES ALL VISIBLE AIR BUBBLES DURING THE AUTOMATIC PRIMING PROCESS OF HEMODIALYSIS MACHINES
Nephrology Dialysis Transplantation, 58th ERA-EDTA Congress, May 2021
Summary: Utility of a novel needle cap that completely eliminates visible microbubbles during the automatic priming process
P1364 CATIONIC CELLULOSE BASED PAD STOPS BLEEDING WITHIN FIVE MINUTES AFTER HEMODIALYSIS
Nephrology Dialysis Transplantation, 57th ERA-EDTA Congress, June 2020
Summary: Rapid hemostasis within 5 minutes post-dialysis using a cationic cellulose pad
Uric acid distribution volume calculated by kinetic modeling and extracellular volume predicted by bioimpedance method.
The International Journal of Artificial Organs, March 23, 2020
DOI: 10.1177/0391398820909835SP578 THE EFFECT OF ELECTROLYTIC WATER ON THE INFECTION RATE OF BUTTONHOLE PUNCTURE
Nephrology Dialysis Transplantation, 56th ERA-EDTA Congress, June 1, 2019
DOI: 10.1093/ndt/gfz103.sp578Correction to: Creation of Straight-Chain Cationic Polysaccharide-Based Bile Salt Sequestrants Made from Euglenoid β-1,3-Glucan as Potential Antidiabetic Agents.
Pharmaceutical Research, January 2, 2019
DOI: 10.1007/s11095-018-2559-2Creation of Straight-Chain Cationic Polysaccharide-Based Bile Salt Sequestrants Made from Euglenoid β-1,3-Glucan as Potential Antidiabetic Agents.
Pharmaceutical Research, December 6, 2018
Summary: Development of linear cationic polysaccharides from Euglena as antidiabetic agents
DOI: 10.1007/s11095-018-2553-8SP581 NEW METHOD TO DECREASE BUTTONHOLE LOCAL INFECTION RATE TO LESS THAN 1 IN 10,000
Nephrology Dialysis Transplantation, 54th ERA-EDTA Congress, May 2017
Summary: New method to reduce the local infection rate of buttonhole puncture to less than 1 in 10,000
A New Method That Enables Complete Removal of Scabs at Buttonhole Entry Sites.
Contributions to Nephrology, August 5, 2015
Summary: New method enabling complete removal of scabs at buttonhole entry sites
DOI: 10.1159/000431166SP585 BUTTONHOLE NEEDLING COME TO BE AS SAFE AS ROPE-LADDER PUNCTURE METHOD BY USING MOIST WOUND HEALING METHOD
Nephrology Dialysis Transplantation, 52nd ERA-EDTA Congress, May 2015
DOI: 10.1093/ndt/gfv198.08Acceleration of iron utilization after intravenous iron administration during activated erythropoiesis in hemodialysis patients: a randomized study.
Therapeutic Apheresis and Dialysis, September 26, 2014
DOI: 10.1111/1744-9987.12237Randomized Trial comparing New Chitosan-Based Bandage with Kaltostat Hemostatic Dressing to Control Bleeding from Hemodialysis Puncture Site
49th ERA-EDTA Congress, Paris, May 2012
Summary: Randomized trial comparing a new chitosan-based hemostatic bandage with conventional hemostatic dressings
Poster Session 1
NDT plus, June 1, 2008